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Updates on Covid-19 drug development: Therapeutic drug alone isn’t enough

The Results Are In with Dr. Sanjay Gupta

We’ve talked a lot about the use of the antiviral drug remdesivir in very ill coronavirus patients. Now we know a bit more about the thinking of how it is suggested to be used, after researchers published the data that led the US government to recommend its use.

The data, published in the New England Journal of Medicine, showed the drug shortened the course of illness from an average of 15 days to about 11 days.

The researchers said a 10-day course of the drug was better than the placebo used. But was not a cure and it did not act quickly.

They said the study showed “it is clear that treatment with an antiviral drug alone is not likely to be sufficient.” And they suggested the goal be for researchers to look at using a combination of therapeutics.

The drug hydroxychloroquine has been touted by the President, and in fact he says he took it, despite federal health officials saying it hasn’t been shown to work to treat or prevent coronavirus infection, and might be dangerous.

There are also serious concerns about the use of the drug in patients who have coronavirus, according to a large observational study published in the medical journal The Lancet.

Seriously ill Covid-19 patients who were given the drug were more likely to die or develop dangerous irregular heart rhythms, according to the study.

Because of the study’s results, the World Health Organization announced Monday that it is temporarily pausing studying hydroxychloroquine due to the safety concerns raised.
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Having coronavirus without the symptoms

About a third of coronavirus infections are asymptomatic, the US Centers for Disease Control and Prevention estimates. The agency also estimates that 40% of coronavirus transmission occurs before people feel sick.

Those numbers were disclosed in new guidance for mathematical modelers and public health officials. The data also includes scenarios that include mortality rates.

That data could change as more is learned about Covid-19, the CDC notes, and it says the numbers are meant only for planning purposes. The numbers are based on real data collected by the CDC before May.

The numbers are part of five planning scenarios that “are being used by mathematical modelers throughout the federal government,” according to the CDC.

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A second peak instead of a wave?

Right now, we are “right in the middle of the first wave, globally,” and still in a phase where Covid-19 is actually on the way up, according to World Health Organization officials.

The health group on Monday warned of a second peak – not necessarily a second wave – of coronavirus cases.

Dr. Mike Ryan, executive director of WHO’s Health Emergencies Programme, explained that his organization believes we are “right in the middle of the first wave, globally,” adding, “we’re still very much in a phase where the disease is actually on the way up.”

This should be a warning to all countries, the group said, not to become complacent if numbers go down, especially when it comes to flu season.
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Credit: CNN Health

 

13 thoughts on “Updates on Covid-19 drug development: Therapeutic drug alone isn’t enough

  1. At least the smartest man in America has taken HCQ to prevent COVID19. too bad he’s not smart enough to Fire Fauci that might have saved 100K US Lives.

    1. Your use of the English language, poor punctuation, and lack of knowledge about where capital letters belong and don’t belong has me ignoring your opinion, and asking myself what grade you completed and what fly over state you are from.

    2. Your use of the English language, poor punctuation, and lack of knowledge about where capital letters belong and don’t belong has me ignoring your opinion, and asking myself what grade you completed and what fly over state you are from.

      1. Please read the CHL policy on commenting. Contributions must refer to the subject at hand. Denigrating, and shaming are not permitted.

        1. Was it the fly over state comment or the poor English language skills that you have a problem with. And Mikeydogs2 comment is ok?

  2. not only did Pres Trump take HCQ but so did the President of El Salvador. He reports that all the leaders around the world were told to take it as a preventive in Mid January. So good enough for them, but “dangerous” for everyone else although around for over 60 years, over 40K doses given to the armed forces daily, taken by millions for Rheumatoid arthritis and fibromyalgia, and multiple reports from doctors around the world in communities and nursing homes that it works. the Chloroquine has a higher likelihood of cardiac issues. The HCQ has minimal side effects given the huge numbers of people around the world who take it daily. It opens up the cells so they can get oxygen and the zinc slows down the viral replication.

    Follow the money to understand why a 30 cent pill suddenly is “concerning” and of course the media keeps building the fear factor for a thing that peaked in mid April. time to get on with life and not live in fear. Looks like even EC has finally figured that out.

    and fauci knew it worked back in 2005 when he published an article in a well known virology magazine;

    https://onenewsnow.com/perspectives/bryan-fischer/2020/04/27/fauci-knew-about-hcq-in-2005-nobody-needed-to-die

    1. Very good points and thanks for the link. I’m in Seattle and oscillate between FOX and CNN to get both sides of a story. FOX reports lightly on the virus, mostly on current corruption in Washington, as opposed to CNN, it’s virus, virus, virus.

    2. Wow, that was a mouthful.

      So glad we have someone who is as well connected to all he world leaders as you are. Thank god Doctor Trump is here to save all of us. And you say Trump knew this in mid January?

      Slow, slow, slow.

    3. Your comments are beyond foolish. Good grief. Did you read the article? It is not easy to be as misinformed as you are. You would be wise to refrain from commenting in the future. Also, there’s 2 solid endorsers whose recommendations we should all follow: Donald Trump and the President of El Salvador.

    4. Reason politicians are taking it, because it works.Why is the drug not available to everybody?

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